Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

IMPORTANCE: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disor...

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Bibliografische gegevens
Gepubliceerd in:JAMA Neurol
Hoofdauteurs: Bridel, Claire, van Wieringen, Wessel N., Zetterberg, Henrik, Tijms, Betty M., Teunissen, Charlotte E., Alvarez-Cermeño, José C., Andreasson, Ulf, Axelsson, Markus, Bäckström, David C., Bartos, Ales, Bjerke, Maria, Blennow, Kaj, Boxer, Adam, Brundin, Lou, Burman, Joachim, Christensen, Tove, Fialová, Lenká, Forsgren, Lars, Frederiksen, Jette L., Gisslén, Magnus, Gray, Elizabeth, Gunnarsson, Martin, Hall, Sara, Hansson, Oskar, Herbert, Megan K., Jakobsson, Joel, Jessen-Krut, Jan, Janelidze, Shorena, Johannsson, Gudmundur, Jonsson, Michael, Kappos, Ludwig, Khademi, Mohsen, Khalil, Michael, Kuhle, Jens, Landén, Mikael, Leinonen, Ville, Logroscino, Giancarlo, Lu, Ching-Hua, Lycke, Jan, Magdalinou, Nadia K., Malaspina, Andrea, Mattsson, Niklas, Meeter, Lieke H., Mehta, Sanjay R., Modvig, Signe, Olsson, Tomas, Paterson, Ross W., Pérez-Santiago, Josué, Piehl, Fredrik, Pijnenburg, Yolande A. L., Pyykkö, Okko T., Ragnarsson, Oskar, Rojas, Julio C., Romme Christensen, Jeppe, Sandberg, Linda, Scherling, Carole S., Schott, Jonathan M., Sellebjerg, Finn T., Simone, Isabella L., Skillbäck, Tobias, Stilund, Morten, Sundström, Peter, Svenningsson, Anders, Tortelli, Rosanna, Tortorella, Carla, Trentini, Alessandro, Troiano, Maria, Turner, Martin R., van Swieten, John C., Vågberg, Mattias, Verbeek, Marcel M., Villar, Luisa M., Visser, Pieter Jelle, Wallin, Anders, Weiss, Andreas, Wikkelsø, Carsten, Wild, Edward J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Medical Association 2019
Onderwerpen:
Original Investigation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580449/
https://ncbi.nlm.nih.gov/pubmed/31206160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1534
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