Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

IMPORTANCE: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disor...

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Publié dans:JAMA Neurol
Auteurs principaux: Bridel, Claire, van Wieringen, Wessel N., Zetterberg, Henrik, Tijms, Betty M., Teunissen, Charlotte E., Alvarez-Cermeño, José C., Andreasson, Ulf, Axelsson, Markus, Bäckström, David C., Bartos, Ales, Bjerke, Maria, Blennow, Kaj, Boxer, Adam, Brundin, Lou, Burman, Joachim, Christensen, Tove, Fialová, Lenká, Forsgren, Lars, Frederiksen, Jette L., Gisslén, Magnus, Gray, Elizabeth, Gunnarsson, Martin, Hall, Sara, Hansson, Oskar, Herbert, Megan K., Jakobsson, Joel, Jessen-Krut, Jan, Janelidze, Shorena, Johannsson, Gudmundur, Jonsson, Michael, Kappos, Ludwig, Khademi, Mohsen, Khalil, Michael, Kuhle, Jens, Landén, Mikael, Leinonen, Ville, Logroscino, Giancarlo, Lu, Ching-Hua, Lycke, Jan, Magdalinou, Nadia K., Malaspina, Andrea, Mattsson, Niklas, Meeter, Lieke H., Mehta, Sanjay R., Modvig, Signe, Olsson, Tomas, Paterson, Ross W., Pérez-Santiago, Josué, Piehl, Fredrik, Pijnenburg, Yolande A. L., Pyykkö, Okko T., Ragnarsson, Oskar, Rojas, Julio C., Romme Christensen, Jeppe, Sandberg, Linda, Scherling, Carole S., Schott, Jonathan M., Sellebjerg, Finn T., Simone, Isabella L., Skillbäck, Tobias, Stilund, Morten, Sundström, Peter, Svenningsson, Anders, Tortelli, Rosanna, Tortorella, Carla, Trentini, Alessandro, Troiano, Maria, Turner, Martin R., van Swieten, John C., Vågberg, Mattias, Verbeek, Marcel M., Villar, Luisa M., Visser, Pieter Jelle, Wallin, Anders, Weiss, Andreas, Wikkelsø, Carsten, Wild, Edward J.
Format: Artigo
Langue:Inglês
Publié: American Medical Association 2019
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580449/
https://ncbi.nlm.nih.gov/pubmed/31206160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1534
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