Telomere Maintenance-Associated PML Is a Potential Specific Therapeutic Target of Human Colorectal Cancer

Telomere length maintenance is essential for cell proliferation, which is particularly prominent in cancer. We validate that the primary colorectal tumors exhibit heterogeneous telomere lengths but mostly (90%) short telomeres relative to normal tissues. Intriguingly, relatively short telomeres are...

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Vydáno v:Transl Oncol
Hlavní autoři: Gong, Peng, Wang, Hua, Zhang, Jingsong, Fu, Yudong, Zhu, Zhengmao, Wang, Jinmiao, Yin, Yu, Wang, Haiying, Zhou, Zhongcheng, Yang, Jiao, Liu, Linlin, Gou, Mo, Zeng, Ming, Yuan, Jinghua, Wang, Feng, Pan, Xinghua, Xiang, Rong, Weissman, Sherman M., Qi, Feng, Liu, Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2019
Témata:
Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580093/
https://ncbi.nlm.nih.gov/pubmed/31207547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.05.010
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