An unbiased in vitro screen for activating epidermal growth factor receptor mutations

Cancer tissues harbor thousands of mutations, and a given oncogene may be mutated at hundreds of sites, yet only a few of these mutations have been functionally tested. Here, we describe an unbiased platform for the functional characterization of thousands of variants of a single receptor tyrosine k...

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Publicado no:J Biol Chem
Main Authors: Chakroborty, Deepankar, Kurppa, Kari J., Paatero, Ilkka, Ojala, Veera K., Koivu, Marika, Tamirat, Mahlet Z., Koivunen, Jussi P., Jänne, Pasi A., Johnson, Mark S., Elo, Laura L., Elenius, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579474/
https://ncbi.nlm.nih.gov/pubmed/30952700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006336
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