Phenotypic Alteration of a Human BK (hSlo) Channel byhSloβ Subunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation

A human homolog of the large-conductance calcium-activated potassium (BK) channel β subunit (hSloβ) was cloned, and its effects on a human BK channel (hSlo) phenotype are reported. Coexpression of hSlo and hSloβ, in both oocytes and human embryonic kidney 293 cells, resulted in increased Ca(2+) sens...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Dworetzky, Steven I., Boissard, Christopher G., Lum-Ragan, Janet T., McKay, M. Craig, Post-Munson, Debra J., Trojnacki, Joanne T., Chang, Chia-Ping, Gribkoff, Valentin K.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1996
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579031/
https://ncbi.nlm.nih.gov/pubmed/8764643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-15-04543.1996
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