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Stimulatory Action of Internal Protons on Slo1 BK Channels

We investigated the internal pH-sensitivity of heterologously expressed hSlo1 BK channels. In the virtual absence of Ca(2+) and Mg(2+) to isolate the voltage-dependent gating transitions, low internal pH enhanced macroscopic hSlo1 currents by shifting the voltage-dependence of activation to more neg...

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Autores principales: Avdonin, Vladimir, Tang, Xiang Dong, Hoshi, Toshinori
Formato: Artigo
Lenguaje:Inglês
Publicado: Biophysical Society 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302859/
https://ncbi.nlm.nih.gov/pubmed/12719228
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