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Reciprocal regulation of the Ca(2+) and H(+) sensitivity in the Slo1 BK channel conferred by the RCK1 domain

Increasing evidence suggests that intracellular H(+) directly stimulates large-conductance Ca(2+)- and voltage-activated K(+) (Slo1 BK) channels, thus providing a crucial link between membrane excitability and cell metabolism. Here we report that two histidine residues, His365 and His394, located in...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Hou, Shangwei, Xu, Rong, Heinemann, Stefan H., Hoshi, Toshinori
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905141/
https://ncbi.nlm.nih.gov/pubmed/18345016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1398
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