Two distinct effects of PIP(2) underlie auxiliary subunit-dependent modulation of Slo1 BK channels

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) plays a critical role in modulating the function of numerous ion channels, including large-conductance Ca(2+)- and voltage-dependent K(+) (BK, Slo1) channels. Slo1 BK channel complexes include four pore-forming Slo1 (α) subunits as well as various regul...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Tian, Yutao, Ullrich, Florian, Xu, Rong, Heinemann, Stefan H., Hou, Shangwei, Hoshi, Toshinori
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380209/
https://ncbi.nlm.nih.gov/pubmed/25825171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511363
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