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Reciprocal regulation of the Ca(2+) and H(+) sensitivity in the Slo1 BK channel conferred by the RCK1 domain
Increasing evidence suggests that intracellular H(+) directly stimulates large-conductance Ca(2+)- and voltage-activated K(+) (Slo1 BK) channels, thus providing a crucial link between membrane excitability and cell metabolism. Here we report that two histidine residues, His365 and His394, located in...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905141/ https://ncbi.nlm.nih.gov/pubmed/18345016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1398 |
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