TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death

Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (−/−) mice have a significant increase in apoptotic cell death in different...

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Publicado en:J Neurosci
Autores principales: Alcántara, Soledad, Frisén, Jonas, del Río, José Antonio, Soriano, Eduardo, Barbacid, Mariano, Silos-Santiago, Inmaculada
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 1997
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573670/
https://ncbi.nlm.nih.gov/pubmed/9133385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-10-03623.1997
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