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TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death

Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (−/−) mice have a significant increase in apoptotic cell death in different...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Alcántara, Soledad, Frisén, Jonas, del Río, José Antonio, Soriano, Eduardo, Barbacid, Mariano, Silos-Santiago, Inmaculada
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573670/
https://ncbi.nlm.nih.gov/pubmed/9133385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-10-03623.1997
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