Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models(✰)

BACKGROUND: Autologous hepatocyte transplantation after ex vivo gene therapy is an alternative to liver transplantation for metabolic liver disease. Here we evaluate ex vivo gene therapy followed by transplantation of single-cell or spheroid hepatocytes. METHODS: Pig and mouse hepatocytes were isola...

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Publicat a:Surgery
Autors principals: Nicolas, Clara T., Hickey, Raymond D., Allen, Kari L., Du, Zeji, Guthman, Rebekah M., Kaiser, Robert A., Amiot, Bruce, Bansal, Aditya, Pandey, Mukesh K., Suksanpaisan, Lukkana, DeGrado, Timothy R, Nyberg, Scott L., Lillegard, Joseph B.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573031/
https://ncbi.nlm.nih.gov/pubmed/29884476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2018.04.012
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