Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease. However, a major limitation of this approach in quiescent adult primary hepatocytes is that nonhomologous en...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: VanLith, Caitlin J., Guthman, Rebekah M., Nicolas, Clara T., Allen, Kari L., Liu, Yuanhang, Chilton, Jennifer A., Tritz, Zachariah P., Nyberg, Scott L., Kaiser, Robert A., Lillegard, Joseph B., Hickey, Raymond D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442694/
https://ncbi.nlm.nih.gov/pubmed/30976745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1315
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