Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease. However, a major limitation of this approach in quiescent adult primary hepatocytes is that nonhomologous en...

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Bibliografiske detaljer
Udgivet i:Hepatol Commun
Main Authors: VanLith, Caitlin J., Guthman, Rebekah M., Nicolas, Clara T., Allen, Kari L., Liu, Yuanhang, Chilton, Jennifer A., Tritz, Zachariah P., Nyberg, Scott L., Kaiser, Robert A., Lillegard, Joseph B., Hickey, Raymond D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442694/
https://ncbi.nlm.nih.gov/pubmed/30976745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1315
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