Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease. However, a major limitation of this approach in quiescent adult primary hepatocytes is that nonhomologous en...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hepatol Commun
Egile Nagusiak: VanLith, Caitlin J., Guthman, Rebekah M., Nicolas, Clara T., Allen, Kari L., Liu, Yuanhang, Chilton, Jennifer A., Tritz, Zachariah P., Nyberg, Scott L., Kaiser, Robert A., Lillegard, Joseph B., Hickey, Raymond D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442694/
https://ncbi.nlm.nih.gov/pubmed/30976745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1315
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