A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant

INTRODUCTION: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its orally active prodrug, capecitabine, are widely used in the treatment of gastrointestinal cancer, including colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) plays an important role in the 5-FU metabolism. Dihydropyrimidine...

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Detalhes bibliográficos
Publicado no:Medicine (Baltimore)
Main Authors: De Falco, Vincenzo, Natalicchio, Maria Iole, Napolitano, Stefania, Coppola, Nicola, Conzo, Giovanni, Martinelli, Erika, Zanaletti, Nicoletta, Vitale, Pasquale, Giunta, Emilio Francesco, Vietri, Maria Teresa, Vitiello, Pietro Paolo, Ciardiello, Davide, Marinaccio, Anna, De Vita, Ferdinando, Ciardiello, Fortunato, Troiani, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571425/
https://ncbi.nlm.nih.gov/pubmed/31124962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000015759
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