A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant

INTRODUCTION: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its orally active prodrug, capecitabine, are widely used in the treatment of gastrointestinal cancer, including colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) plays an important role in the 5-FU metabolism. Dihydropyrimidine...

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Detaylı Bibliyografya
Yayımlandı:Medicine (Baltimore)
Asıl Yazarlar: De Falco, Vincenzo, Natalicchio, Maria Iole, Napolitano, Stefania, Coppola, Nicola, Conzo, Giovanni, Martinelli, Erika, Zanaletti, Nicoletta, Vitale, Pasquale, Giunta, Emilio Francesco, Vietri, Maria Teresa, Vitiello, Pietro Paolo, Ciardiello, Davide, Marinaccio, Anna, De Vita, Ferdinando, Ciardiello, Fortunato, Troiani, Teresa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wolters Kluwer Health 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571425/
https://ncbi.nlm.nih.gov/pubmed/31124962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000015759
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