A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant

INTRODUCTION: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its orally active prodrug, capecitabine, are widely used in the treatment of gastrointestinal cancer, including colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) plays an important role in the 5-FU metabolism. Dihydropyrimidine...

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Enregistré dans:
Détails bibliographiques
Publié dans:Medicine (Baltimore)
Auteurs principaux: De Falco, Vincenzo, Natalicchio, Maria Iole, Napolitano, Stefania, Coppola, Nicola, Conzo, Giovanni, Martinelli, Erika, Zanaletti, Nicoletta, Vitale, Pasquale, Giunta, Emilio Francesco, Vietri, Maria Teresa, Vitiello, Pietro Paolo, Ciardiello, Davide, Marinaccio, Anna, De Vita, Ferdinando, Ciardiello, Fortunato, Troiani, Teresa
Format: Artigo
Langue:Inglês
Publié: Wolters Kluwer Health 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571425/
https://ncbi.nlm.nih.gov/pubmed/31124962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MD.0000000000015759
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