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Bcl3 phosphorylation by Akt, Erk2 and IKK is required for its transcriptional activity
Unlike prototypical IκB proteins which are inhibitors of NF-κB RelA, cRel, and RelB dimers; the atypical IκB protein Bcl3 is primarily a transcriptional coregulator of p52 and p50 homodimers. Bcl3 exists as phospho-protein in many cancer cells. Unphosphorylated Bcl3 acts as classical IκB-like inhibi...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6571149/ https://ncbi.nlm.nih.gov/pubmed/28689659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.011 |
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