Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies

The blood-brain barrier (BBB) is essential for proper neuronal function, homeostasis, and protection of the central nervous system (CNS) microenvironment from blood-borne pathogens and neurotoxins. The BBB is also an impediment for CNS penetration of drugs. In some neurologic conditions, such as epi...

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Bibliographic Details
Published in:AAPS J
Main Authors: Mohamed, Loqman A., Markandaiah, Shashirekha, Bonanno, Silvia, Pasinelli, Piera, Trotti, Davide
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571115/
https://ncbi.nlm.nih.gov/pubmed/28779378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0120-6
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