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Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis

Synaptic accumulation of glutamate causes neuronal death in many neurodegenerative pathologies such as amyotrophic lateral sclerosis. Drugs capable of increasing glutamate uptake could therefore be therapeutically effective. We screened in a cell-based assay a library of 1040 FDA-approved drugs and...

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Detalhes bibliográficos
Main Authors: Boston-Howes, William, Williams, Eric O., Bogush, Alexey, Scolere, Maura, Pasinelli, Piera, Trotti, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600491/
https://ncbi.nlm.nih.gov/pubmed/18625223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.06.010
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