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Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis

Synaptic accumulation of glutamate causes neuronal death in many neurodegenerative pathologies such as amyotrophic lateral sclerosis. Drugs capable of increasing glutamate uptake could therefore be therapeutically effective. We screened in a cell-based assay a library of 1040 FDA-approved drugs and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Boston-Howes, William, Williams, Eric O., Bogush, Alexey, Scolere, Maura, Pasinelli, Piera, Trotti, Davide
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600491/
https://ncbi.nlm.nih.gov/pubmed/18625223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.06.010
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