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Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis
Synaptic accumulation of glutamate causes neuronal death in many neurodegenerative pathologies such as amyotrophic lateral sclerosis. Drugs capable of increasing glutamate uptake could therefore be therapeutically effective. We screened in a cell-based assay a library of 1040 FDA-approved drugs and...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2600491/ https://ncbi.nlm.nih.gov/pubmed/18625223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.06.010 |
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