Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces CNS penetration and efficacy of the ALS drug, riluzole. Post-mortem spinal cord tissues from ALS patients revealed elevated...

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Publicado en:Exp Neurol
Autores principales: Mohamed, Loqman A., Markandaiah, Shashirekha, Bonanno, Silvia, Pasinelli, Piera, Trotti, Davide
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506236/
https://ncbi.nlm.nih.gov/pubmed/30974102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.04.002
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