Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

BACKGROUND: Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathway is in...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Transl Neurodegener
Autori principali: Wu, Jia-Zhen, Ardah, Mustafa, Haikal, Caroline, Svanbergsson, Alexander, Diepenbroek, Meike, Vaikath, Nishant N., Li, Wen, Wang, Zhan-You, Outeiro, Tiago F., El-Agnaf, Omar M., Li, Jia-Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570948/
https://ncbi.nlm.nih.gov/pubmed/31223479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0159-7
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