Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

BACKGROUND: Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathway is in...

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Vydáno v:Transl Neurodegener
Hlavní autoři: Wu, Jia-Zhen, Ardah, Mustafa, Haikal, Caroline, Svanbergsson, Alexander, Diepenbroek, Meike, Vaikath, Nishant N., Li, Wen, Wang, Zhan-You, Outeiro, Tiago F., El-Agnaf, Omar M., Li, Jia-Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570948/
https://ncbi.nlm.nih.gov/pubmed/31223479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0159-7
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