Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes

BACKGROUND: α-Calcitonin gene-related peptide (α-CGRP) is a 37-amino acid neuropeptide involved in several pathophysiological processes. α-CGRP is involved in the regulation of cholangiocyte proliferation during cholestasis. In this study, we aimed to evaluate if α-CGRP regulates bile duct ligation...

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Bibliographic Details
Published in:Lab Invest
Main Authors: Wan, Ying, Ceci, Ludovica, Wu, Nan, Zhou, Tianhao, Chen, Lixian, Venter, Julie, Francis, Heather, Bernuzzi, Francesca, Invernizzi, Pietro, Kyritsi, Konstantina, Baker, Paul, Huang, Qiaobing, Wu, Chaodong, Sybenga, Amelia, Alpini, Gianfranco, Meng, Fanyin, Glaser, Shannon
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570540/
https://ncbi.nlm.nih.gov/pubmed/30700848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-018-0178-5
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