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Sensitization of Nociceptors and Dorsal Horn Neurons Contributes to Pain in Sickle Cell Disease

Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle r...

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Publicado en:Neurosci Lett
Main Authors: Uhelski, Megan L., Simone, Donald A.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570534/
https://ncbi.nlm.nih.gov/pubmed/30995520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.04.013
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