Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We generated genetically engineered inducible mice and showed that H3.3 K27M enhanced neural stem cell self-renewal while preservin...

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Bibliografski detalji
Izdano u:Cancer Cell
Glavni autori: Larson, Jon D., Kasper, Lawryn H., Paugh, Barbara S., Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I., Silveira, André B., Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R., Peters, Jennifer L., Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L., Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B., McKinnon, Peter J., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570409/
https://ncbi.nlm.nih.gov/pubmed/30595505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.11.015
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