H3.3 K27M Depletion Increases Differentiation and Extends Latency of Diffuse Intrinsic Pontine Glioma Growth In Vivo

Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the contribution of the mutation to disease pathogenesis remains unclear....

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發表在:Acta Neuropathol
Main Authors: Silveira, André B., Kasper, Lawryn H., Fan, Yiping, Jin, Hongjian, Wu, Gang, Shaw, Timothy I., Zhu, Xiaoyan, Larson, Jon D., Easton, John, Shao, Ying, Yergeau, Donald A., Rosencrance, Celeste, Boggs, Kristy, Rusch, Michael C., Ding, Liang, Zhang, Junyuan, Finkelstein, David, Noyes, Rachel M., Russell, Brent L., Xu, Beisi, Broniscer, Alberto, Wetmore, Cynthia, Pounds, Stanley B., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546611/
https://ncbi.nlm.nih.gov/pubmed/30770999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01975-4
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