Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We generated genetically engineered inducible mice and showed that H3.3 K27M enhanced neural stem cell self-renewal while preservin...

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書誌詳細
出版年:Cancer Cell
主要な著者: Larson, Jon D., Kasper, Lawryn H., Paugh, Barbara S., Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I., Silveira, André B., Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R., Peters, Jennifer L., Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L., Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B., McKinnon, Peter J., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570409/
https://ncbi.nlm.nih.gov/pubmed/30595505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.11.015
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