Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We generated genetically engineered inducible mice and showed that H3.3 K27M enhanced neural stem cell self-renewal while preservin...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell
Egile Nagusiak: Larson, Jon D., Kasper, Lawryn H., Paugh, Barbara S., Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I., Silveira, André B., Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R., Peters, Jennifer L., Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L., Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B., McKinnon, Peter J., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570409/
https://ncbi.nlm.nih.gov/pubmed/30595505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.11.015
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