H3.3 K27M Depletion Increases Differentiation and Extends Latency of Diffuse Intrinsic Pontine Glioma Growth In Vivo

Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the contribution of the mutation to disease pathogenesis remains unclear....

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Publicado no:Acta Neuropathol
Main Authors: Silveira, André B., Kasper, Lawryn H., Fan, Yiping, Jin, Hongjian, Wu, Gang, Shaw, Timothy I., Zhu, Xiaoyan, Larson, Jon D., Easton, John, Shao, Ying, Yergeau, Donald A., Rosencrance, Celeste, Boggs, Kristy, Rusch, Michael C., Ding, Liang, Zhang, Junyuan, Finkelstein, David, Noyes, Rachel M., Russell, Brent L., Xu, Beisi, Broniscer, Alberto, Wetmore, Cynthia, Pounds, Stanley B., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546611/
https://ncbi.nlm.nih.gov/pubmed/30770999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01975-4
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