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Desensitization of acetylcholine receptors in rat myotubes is enhanced by agents that elevate intracellular cAMP

Incubating skeletal muscle fibers with forskolin, an activator of adenylate cyclase, increases the rate at which nicotinic acetylcholine receptors (AChRs) desensitize when exposed to ACh. Several reports indicate that this is due to the phosphorylation of AChRs by cAMP- dependent protein kinase, but...

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Pubblicato in:J Neurosci
Autori principali: Middleton, P, Rubin, LL, Schuetze, SM
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1988
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6569451/
https://ncbi.nlm.nih.gov/pubmed/2459325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.08-09-03405.1988
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