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Desensitization of acetylcholine receptors in rat myotubes is enhanced by agents that elevate intracellular cAMP

Incubating skeletal muscle fibers with forskolin, an activator of adenylate cyclase, increases the rate at which nicotinic acetylcholine receptors (AChRs) desensitize when exposed to ACh. Several reports indicate that this is due to the phosphorylation of AChRs by cAMP- dependent protein kinase, but...

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Publicat a:J Neurosci
Autors principals: Middleton, P, Rubin, LL, Schuetze, SM
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1988
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6569451/
https://ncbi.nlm.nih.gov/pubmed/2459325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.08-09-03405.1988
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