Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis

Copper-dependent amine oxidases produce their redox active cofactor, 2,4,5-trihydroxyphenylalanine quinone (TPQ), via the Cu(II)-catalyzed oxygenation of an active site tyrosine. This study addresses possible mechanisms for this biogenesis process by presenting the geometric and electronic structure...

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Publicado no:J Am Chem Soc
Main Authors: Adelson, Charles N., Johnston, Esther M., Hilmer, Kimberly M., Watts, Hope, Dey, Somdatta Ghosh, Brown, Doreen E., Broderick, Joan B., Shepard, Eric M., Dooley, David M., Solomon, Edward I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568004/
https://ncbi.nlm.nih.gov/pubmed/31060358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b01922
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