Structure of the Reduced Copper Active Site in Pre-Processed Galactose Oxidase: Ligand Tuning for One-Electron O(2) Activation in Cofactor Biogenesis

Galactose oxidase (GO) is a copper-dependent enzyme that accomplishes 2e(−) substrate oxidation by pairing a single copper with an unusual cysteinylated tyrosine (Cys-Tyr) redox cofactor. Previous studies have demonstrated that the post-translational biogenesis of Cys-Tyr is copper- and O(2)-depende...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Cowley, Ryan E., Cirera, Jordi, Qayyum, Munzarin F., Rokhsana, Dalia, Hedman, Britt, Hodgson, Keith O., Dooley, David M., Solomon, Edward I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061629/
https://ncbi.nlm.nih.gov/pubmed/27626829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b05792
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