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Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

Background: Islet autophagy plays a role in glucose/lipid metabolism in type 2 diabetes mellitus. Meanwhile, fibroblast growth factor 21 (FGF21) has been found to regulate insulin sensitivity and glucose homeostasis. Whether FGF21 induces islet autophagy, remains to be elucidated. This study aimed t...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Cheng, Sam Tsz Wai, Li, Stephen Yu Ting, Leung, Po Sing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567208/
https://ncbi.nlm.nih.gov/pubmed/31121855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102517
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