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Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

Background: Islet autophagy plays a role in glucose/lipid metabolism in type 2 diabetes mellitus. Meanwhile, fibroblast growth factor 21 (FGF21) has been found to regulate insulin sensitivity and glucose homeostasis. Whether FGF21 induces islet autophagy, remains to be elucidated. This study aimed t...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Cheng, Sam Tsz Wai, Li, Stephen Yu Ting, Leung, Po Sing
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567208/
https://ncbi.nlm.nih.gov/pubmed/31121855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102517
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