Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction

Nine indole derivatives (9a-i) were tested as potential inhibitors of the Keap1–Nrf2 interaction. This class of compounds increases the intracellular levels of the transcription factor Nrf2 and the consequent expression of enzymes encoded by genes containing the antioxidant response element (ARE). I...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Cosimelli, Barbara, Greco, Giovanni, Laneri, Sonia, Novellino, Ettore, Sacchi, Antonia, Amendola, Giorgio, Cosconati, Sandro, Bortolozzi, Roberta, Viola, Giampietro
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567006/
https://ncbi.nlm.nih.gov/pubmed/31179771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1623209
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