Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction

Nine indole derivatives (9a-i) were tested as potential inhibitors of the Keap1–Nrf2 interaction. This class of compounds increases the intracellular levels of the transcription factor Nrf2 and the consequent expression of enzymes encoded by genes containing the antioxidant response element (ARE). I...

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Publicat a:J Enzyme Inhib Med Chem
Autors principals: Cosimelli, Barbara, Greco, Giovanni, Laneri, Sonia, Novellino, Ettore, Sacchi, Antonia, Amendola, Giorgio, Cosconati, Sandro, Bortolozzi, Roberta, Viola, Giampietro
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567006/
https://ncbi.nlm.nih.gov/pubmed/31179771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1623209
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