Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Although destructive airways disease is evident in young children with cystic fibrosis (CF), little is known about the nature of the early CF lung environment triggering the disease. To elucidate early CF pulmonary pathophysiology, we performed mucus, inflammation, metabolomic, and microbiome analys...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Esther, Charles R., Muhlebach, Marianne S., Ehre, Camille, Hill, David B., Wolfgang, Matthew C., Kesimer, Mehmet, Ramsey, Kathryn A., Markovetz, Matthew R., Garbarine, Ian C., Forest, M. Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B., Delion, Martial F., Thelin, William R., Villalon, Diane, Sabater, Juan R., Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M., Boucher, Richard C.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566903/
https://ncbi.nlm.nih.gov/pubmed/30944166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav3488
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