Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Although destructive airways disease is evident in young children with cystic fibrosis (CF), little is known about the nature of the early CF lung environment triggering the disease. To elucidate early CF pulmonary pathophysiology, we performed mucus, inflammation, metabolomic, and microbiome analys...

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Pubblicato in:Sci Transl Med
Autori principali: Esther, Charles R., Muhlebach, Marianne S., Ehre, Camille, Hill, David B., Wolfgang, Matthew C., Kesimer, Mehmet, Ramsey, Kathryn A., Markovetz, Matthew R., Garbarine, Ian C., Forest, M. Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B., Delion, Martial F., Thelin, William R., Villalon, Diane, Sabater, Juan R., Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M., Boucher, Richard C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566903/
https://ncbi.nlm.nih.gov/pubmed/30944166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav3488
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