Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Although destructive airways disease is evident in young children with cystic fibrosis (CF), little is known about the nature of the early CF lung environment triggering the disease. To elucidate early CF pulmonary pathophysiology, we performed mucus, inflammation, metabolomic, and microbiome analys...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Esther, Charles R., Muhlebach, Marianne S., Ehre, Camille, Hill, David B., Wolfgang, Matthew C., Kesimer, Mehmet, Ramsey, Kathryn A., Markovetz, Matthew R., Garbarine, Ian C., Forest, M. Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B., Delion, Martial F., Thelin, William R., Villalon, Diane, Sabater, Juan R., Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M., Boucher, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566903/
https://ncbi.nlm.nih.gov/pubmed/30944166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav3488
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