Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule

Cadmium (Cd(2+)) in the environment is a significant health hazard. Chronic low Cd(2+) exposure mainly results from food and tobacco smoking and causes kidney damage, predominantly in the proximal tubule. Blood Cd(2+) binds to thiol-containing high (e.g., albumin, transferrin) and low molecular weig...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Fels, Johannes, Scharner, Bettina, Zarbock, Ralf, Zavala Guevara, Itzel Pamela, Lee, Wing-Kee, Barbier, Olivier C., Thévenod, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566203/
https://ncbi.nlm.nih.gov/pubmed/31091675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102379
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