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Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway

Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk m...

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Bibliografski detalji
Izdano u:Dev Biol
Glavni autori: Lupu, Floria I., Burnett, Jacob B., Eggenschwile, Jonathan T.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563835/
https://ncbi.nlm.nih.gov/pubmed/29166577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2017.10.022
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