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Chemoenzymatic Cascade Synthesis of Optically Pure Alkanoic Acids by Using Engineered Arylmalonate Decarboxylase Variants

Arylmalonate decarboxylase (AMDase) catalyzes the cofactor‐free asymmetric decarboxylation of prochiral arylmalonic acids and produces the corresponding monoacids with rigorous R selectivity. Alteration of catalytic cysteine residues and of the hydrophobic environment in the active site by protein e...

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Publicat a:Chemistry
Autors principals: Enoki, Junichi, Mügge, Carolin, Tischler, Dirk, Miyamoto, Kenji, Kourist, Robert
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563808/
https://ncbi.nlm.nih.gov/pubmed/30702787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201806339
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