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Chemoenzymatic Cascade Synthesis of Optically Pure Alkanoic Acids by Using Engineered Arylmalonate Decarboxylase Variants

Arylmalonate decarboxylase (AMDase) catalyzes the cofactor‐free asymmetric decarboxylation of prochiral arylmalonic acids and produces the corresponding monoacids with rigorous R selectivity. Alteration of catalytic cysteine residues and of the hydrophobic environment in the active site by protein e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chemistry
Main Authors: Enoki, Junichi, Mügge, Carolin, Tischler, Dirk, Miyamoto, Kenji, Kourist, Robert
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563808/
https://ncbi.nlm.nih.gov/pubmed/30702787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201806339
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