Chemoenzymatic Total Synthesis of Deoxy‐, epi‐, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

Podophyllotoxin is probably the most prominent representative of lignan natural products. Deoxy‐, epi‐, and podophyllotoxin, which are all precursors to frequently used chemotherapeutic agents, were prepared by a stereodivergent biotransformation and a biocatalytic kinetic resolution of the correspo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Lazzarotto, Mattia, Hammerer, Lucas, Hetmann, Michael, Borg, Annika, Schmermund, Luca, Steiner, Lorenz, Hartmann, Peter, Belaj, Ferdinand, Kroutil, Wolfgang, Gruber, Karl, Fuchs, Michael
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563474/
https://ncbi.nlm.nih.gov/pubmed/30920120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900926
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