Chemoenzymatic Total Synthesis of Deoxy‐, epi‐, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

Podophyllotoxin is probably the most prominent representative of lignan natural products. Deoxy‐, epi‐, and podophyllotoxin, which are all precursors to frequently used chemotherapeutic agents, were prepared by a stereodivergent biotransformation and a biocatalytic kinetic resolution of the correspo...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Lazzarotto, Mattia, Hammerer, Lucas, Hetmann, Michael, Borg, Annika, Schmermund, Luca, Steiner, Lorenz, Hartmann, Peter, Belaj, Ferdinand, Kroutil, Wolfgang, Gruber, Karl, Fuchs, Michael
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563474/
https://ncbi.nlm.nih.gov/pubmed/30920120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900926
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