Chemoenzymatic Total Synthesis of Deoxy‐, epi‐, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

Podophyllotoxin is probably the most prominent representative of lignan natural products. Deoxy‐, epi‐, and podophyllotoxin, which are all precursors to frequently used chemotherapeutic agents, were prepared by a stereodivergent biotransformation and a biocatalytic kinetic resolution of the correspo...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lazzarotto, Mattia, Hammerer, Lucas, Hetmann, Michael, Borg, Annika, Schmermund, Luca, Steiner, Lorenz, Hartmann, Peter, Belaj, Ferdinand, Kroutil, Wolfgang, Gruber, Karl, Fuchs, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563474/
https://ncbi.nlm.nih.gov/pubmed/30920120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900926
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