Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis

AIM: We report the prevalence and effect of genetic variability on pharmacokinetic parameters of isoniazid and rifampicin. MATERIALS & METHODS: Genotypes for SLCO1B1, NAT2, PXR, ABCB1 and UGT1A genes were determined using a TaqMan(®) Genotyping OpenArray™. Nonlinear mixed-effects models were use...

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Publicat a:Pharmacogenomics
Autors principals: Naidoo, Anushka, Chirehwa, Maxwell, Ramsuran, Veron, McIlleron, Helen, Naidoo, Kogieleum, Yende-Zuma, Nonhlanhla, Singh, Ravesh, Ncgapu, Sinaye, Adamson, John, Govender, Katya, Denti, Paolo, Padayatchi, Nesri
Format: Artigo
Idioma:Inglês
Publicat: Future Medicine Ltd 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562923/
https://ncbi.nlm.nih.gov/pubmed/30767706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2018-0166
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