A phase 2 study to assess the pharmacokinetics and pharmacodynamics of CPX-351 and its effects on cardiac repolarization in patients with acute leukemias

PURPOSE: Daunorubicin can induce left ventricular dysfunction and QT interval prolongation. This study assessed the effects of CPX-351, a liposomal encapsulation of cytarabine and daunorubicin, on cardiac repolarization. METHODS: Twenty-six adults with acute leukemia were treated with CPX-351 for 1–...

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Detaylı Bibliyografya
Yayımlandı:Cancer Chemother Pharmacol
Asıl Yazarlar: Lin, Tara L., Newell, Laura F., Stuart, Robert K., Michaelis, Laura C., Rubenstein, Eric, Pentikis, Helen S., Callahan, Timothy, Alvarez, Donna, Liboiron, Barry D., Mayer, Lawrence D., Wang, Qi, Banerjee, Kamalika, Louie, Arthur C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2019
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562048/
https://ncbi.nlm.nih.gov/pubmed/31098682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03856-9
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