A phase 2 study to assess the pharmacokinetics and pharmacodynamics of CPX-351 and its effects on cardiac repolarization in patients with acute leukemias

PURPOSE: Daunorubicin can induce left ventricular dysfunction and QT interval prolongation. This study assessed the effects of CPX-351, a liposomal encapsulation of cytarabine and daunorubicin, on cardiac repolarization. METHODS: Twenty-six adults with acute leukemia were treated with CPX-351 for 1–...

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Dettagli Bibliografici
Pubblicato in:Cancer Chemother Pharmacol
Autori principali: Lin, Tara L., Newell, Laura F., Stuart, Robert K., Michaelis, Laura C., Rubenstein, Eric, Pentikis, Helen S., Callahan, Timothy, Alvarez, Donna, Liboiron, Barry D., Mayer, Lawrence D., Wang, Qi, Banerjee, Kamalika, Louie, Arthur C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562048/
https://ncbi.nlm.nih.gov/pubmed/31098682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03856-9
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